Cardiac Dysfunction in Mitochondrial Disease
نویسندگان
چکیده
منابع مشابه
Cardiac Dysfunction in Mitochondrial Disease
(mtDNA) disease and the frequency of cardiac involvement, at least 1 in 10–15,000 of the general population will be affected.4 In 1991, the first mtDNA point mutation in the MT-TL1 gene associated with an MCM was described.5 Since then, several mutations, mostly in mitochondrial tRNA genes, have been associated with different MCM phenotypes. At the end of the 20th century, mutations in several ...
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Mitochondria, are the powerhouses of cells, have their own DNA (mtDNA), regulate the transport of metabolites and ions, and impact cell physiology, survival, and death. Mitochondrial dysfunction, including impaired oxidative phosphorylation, preferentially affects heart function due to an imbalance of energy supply and demand. Recently, mitochondrial mutations and associated mitochondrial dysfu...
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Parkinson’s disease (PD) is the most common neurodegenerative movement disorder characterized by numerous motor symptoms, including bradykinesia, hypokinesia, rigidity, resting tremor, and postural instability and non-motor symptoms, such as autonomic dysfunction, sleep abnormalities, depression, and dementia [1-3]. The motor clinical manifestations are the preferential loss of dopaminergic (DA...
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It is clear from a striking convergence of human tissue studies, neurotoxin models, and genetic models that mitochondrial dysregulation plays a central pathogenic role in Parkinson’s disease (PD) and related neurodegenerative conditions. Impaired mitochondrial quality could result from both increased damage and decreased ability to repair or clear damaged mitochondria. In particular, common def...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2013
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-13-0557